Our bioanalytical team has extensive experience developing and validating robust LC-MS/MS methods to quantify a wide variety of large molecules including peptides, proteins, antibody drug conjugates, and oligonucleotides in diverse biological matrices. We also have the tools and expertise to analyze your large molecules intact, or digest them into unique signature peptides for highly specific and sensitive quantitative analysis.
In recent years, we’ve expanded our capabilities to include protein characterization and proteomic support using mass spectrometry. As part of a comprehensive suite of bioanalytical services, Alliance Pharma provides protein analysis for structural elucidation and peptide sequencing. Our bioanalytical team has broad experience characterizing therapeutic proteins utilizing a variety of high resolution accurate mass (HRAM) instruments. We provide a broad range of services to meet your needs in alignment with ICH Q6B guidance.
Protein characterization services include the following:
• Protein and antibody characterization
• Peptide mapping
• Disulfide bridge and free sulfhydryl analysis
• N-Glycan profiling
• Monosaccharide composition analysis
• Sialic acid analysis
• Assessment of post-translational modifications (PTMs)
• Intact mass and subunit analysis
• Chromatographic profiles
• Proteomics research support
• De novo sequencing
• Native MS of antibody drug conjugates (ADCs) and protein complexes
• Protein identification
We here at Alliance Pharma are excited about using our expertise in protein characterization to support your projects in the months ahead. You can reach us at 610.296.3152 or email@example.com to talk about the next steps in the process, or can request some additional information HERE.