Spent media analysis can provide insight into cell line stability and productivity. Analytes ranging from amino acids, trace metals and metabolites can be detected and quantified through various modalities such as LC-MS and ICP-MS. Here at Alliance Pharma, we have recently added ICP-MS instrumentation (Agilent 8900 Triple Quadrupole ICP-MS) which is profoundly advancing our spent media analysis capabilities. We encourage past and future clients to explore the benefits of ICP-MS spent media analysis:
- Process variability
Identifying bioprocess variability is a major principal of spent media analysis. Detection and identification of such variability can be expensive in terms of time and funding. Our team at Alliance is dedicated to helping clients determine possible parameters contributing to bioprocess variability.
- Low detection/quantification limits
Triple quadrupole MS technology by Agilent has some of the lowest detection limits for commercially available ICP-MS instrumentation. The accompanying software allows for automated method development, allowing our team to truly isolate and monitor bioprocess variability.
- Benefits of ICP-MS
Spent media analysis via ICP-MS allows for the accurate measurement of metals at low concentrations. The ability to characterize nanoparticles in complex environmental, food and biological samples makes it useful for not only pharmaceutical applications, but for agrochemical projects as well.
- Prevent expensive failures